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Severo Salvadori Selected Research

2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acid

8/2010Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
2/2010Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore.
1/2009Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.
7/2004Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
12/2002Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

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Severo Salvadori Research Topics

Disease

9Tics (Tic)
08/2010 - 01/2002
8Pain (Aches)
03/2017 - 09/2002
4Hypoxia (Hypoxemia)
07/2013 - 09/2008
3Neoplasms (Cancer)
01/2018 - 04/2011
3Substance-Related Disorders (Drug Abuse)
03/2017 - 09/2010
3Inflammation (Inflammations)
06/2015 - 08/2009
2Alzheimer Disease (Alzheimer's Disease)
10/2015 - 11/2002
2Alcoholism (Alcohol Abuse)
01/2012 - 01/2002
1Glaucoma
01/2018
1Mental Disorders (Mental Disorder)
03/2017
1Chronic Pain
01/2017
1Hypotension (Low Blood Pressure)
11/2016
1Traumatic Brain Injuries (Traumatic Brain Injury)
10/2015
1Demyelinating Diseases (Demyelinating Disease)
06/2015
1Multiple Sclerosis
06/2015
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
06/2015
1Adenoma (Adenomas)
06/2014
1Thyroid Neoplasms (Thyroid Cancer)
06/2014
1Ovarian Neoplasms (Ovarian Cancer)
02/2014
1Ischemia
07/2012
1Trichomonas Infections
09/2010
1Herpes Simplex
09/2010
1Hypersensitivity (Allergy)
08/2009
1Obesity
08/2009
1Body Weight (Weight, Body)
08/2009
1Osteoporosis
08/2009
1Hemolysis
09/2008
1Parkinson Disease (Parkinson's Disease)
10/2005
1Hypokinesia (Bradykinesia)
10/2005
1Parkinsonian Disorders (Parkinsonism)
10/2005

Drug/Important Bio-Agent (IBA)

6LigandsIBA
03/2017 - 01/2002
6delta Opioid Receptors (delta Opioid Receptor)IBA
07/2012 - 12/2002
5Opioid Receptors (Opioid Receptor)IBA
01/2017 - 06/2006
5Peptides (Polypeptides)IBA
06/2015 - 11/2002
52',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acidIBA
08/2010 - 12/2002
5Opioid Analgesics (Opioids)IBA
03/2010 - 10/2005
4Biological ProductsIBA
03/2017 - 09/2010
4NociceptinIBA
01/2017 - 09/2002
4Proteins (Proteins, Gene)FDA Link
02/2014 - 11/2002
3Pharmaceutical PreparationsIBA
03/2017 - 01/2012
2NeuropeptidesIBA
11/2016 - 10/2005
2Amyloid beta-PeptidesIBA
10/2015 - 11/2002
2CytokinesIBA
06/2015 - 01/2015
2ChemokinesIBA
01/2015 - 08/2009
2Oxygen (Dioxygen)IBA
07/2013 - 09/2008
2Naltrexone (ReVia)FDA LinkGeneric
01/2012 - 08/2009
2Morphine (MS Contin)FDA LinkGeneric
01/2012 - 08/2009
2Freund's AdjuvantIBA
04/2011 - 08/2009
2Glucose (Dextrose)FDA LinkGeneric
08/2009 - 09/2008
2Opioid Peptides (Opioid Peptide)IBA
01/2004 - 01/2002
2AcidsIBA
12/2002 - 01/2002
1Celecoxib (Celebrex)FDA Link
01/2018
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
01/2018
1Protein Isoforms (Isoforms)IBA
01/2018
1Nootropic Agents (Nootropics)IBA
03/2017
1Analgesics (Analgesic Drugs)IBA
03/2017
1Anti-Anxiety Agents (Anxiolytics)IBA
03/2017
16'- fluoro- 4',9'- dihydro- N,N- dimethyl- 4- phenylspiro(cyclohexane- 1,1'(3'H)- pyrano(3,4- b)indol)- 4- amineIBA
01/2017
1CannabinoidsIBA
11/2016
1CB1 Cannabinoid Receptor (CB1 Receptor)IBA
11/2016
1Hemoglobins (Hemoglobin)IBA
11/2016
1hemopressinIBA
11/2016
1Interleukin-10 (Interleukin 10)IBA
06/2015
1InterferonsIBA
06/2015
1InterleukinsIBA
06/2015
1Cytochromes c (Cytochrome c)IBA
06/2014
1StaurosporineIBA
06/2014
1Thymidylate SynthaseIBA
02/2014
1Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA
02/2014
1Brain-Derived Neurotrophic Factor (BDNF)IBA
07/2013
12',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acid (1H- benzimidazol- 2- yl)(carboxymethyl)methylamideIBA
07/2013
1MicroRNAs (MicroRNA)IBA
01/2013
1Opiate AlkaloidsIBA
01/2012
1Naloxone (Narcan)FDA LinkGeneric
01/2012
1Biomarkers (Surrogate Marker)IBA
04/2011
1Antiviral Agents (Antivirals)IBA
09/2010
1Trypan BlueFDA Link
09/2010
12- tyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acidIBA
08/2010
11,2,3,4-tetrahydroisoquinolineIBA
03/2010
1Guanosine 5'-O-(3-Thiotriphosphate)IBA
03/2010
1GlycogenIBA
08/2009
1Insulin (Novolin)FDA Link
08/2009
1MineralsIBA
08/2009
1CholesterolIBA
08/2009
11,2,3,4- tetrahydroisoquinoline- 3- carboxylic acidIBA
01/2009
1Phenylalanine (L-Phenylalanine)FDA Link
01/2009
14- amino- 1,2,4,5- tetrahydro- 2- benzazepin- 3- oneIBA
01/2009
1benzimidazoleIBA
06/2006
1Haloperidol (Haldol)FDA LinkGeneric
10/2005
1Oxidopamine (6 Hydroxydopamine)IBA
10/2005
1hydroxide ionIBA
08/2005
1AminesIBA
08/2005
1AmidesIBA
08/2005
1Lysine (L-Lysine)FDA Link
08/2005
12',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinolinecarbonyl- phenylalanyl- (N(epsilon)- benzyloxycarbonyl)lysineIBA
08/2005
1mu Opioid Receptors (mu Opioid Receptor)IBA
07/2004

Therapy/Procedure

3Therapeutics
06/2015 - 10/2005
1Immunomodulation
01/2015
1Aftercare (After-Treatment)
06/2014
1Subcutaneous Injections
04/2011